DIY Hyaluronic Acid (HA) Serum

A simple, hydrating serum made with high molecular weight hyaluronic acid to help plump, smooth, and support the skin barrier.

Yield: About 6 oz serum

Prep Time: 5 minutes active | 1 hour (or overnight) resting time

What you'll need:

Recommended brands (cosmetic-grade):

Optional:

Equipment:

How to make it

Prepare your workspace. Clean all utensils, containers, and surfaces to avoid contamination.

  1. Combine water + HA powder
    Add distilled water to your glass container.
    Sprinkle the hyaluronic acid powder over the surface of the water.
    Cover tightly and shake vigorously.
    The mixture will look clumpy—this is normal.

  2. Rest & hydrate
    Refrigerate the covered mixture for at least 1 hour, or until fully dissolved. Overnight is preferred.

  3. Add optional ingredients
    Once the serum has set, stir in Vitamin E oil if using, until well combined.

  4. Store the serum
    Transfer to a dark glass bottle to protect from light.
    Store in the refrigerator.

Storage & Shelf Life

  • Keep refrigerated for 1–2 weeks.

  • Discard if you notice discoloration or a change in smell.

  • When in doubt, make a fresh batch.

How to Use

  • Apply to damp skin to help hyaluronic acid draw in moisture.

  • Follow with a plant oil (like argan or jojoba) or your favorite moisturizer to seal it in.

Notes

  • High molecular weight hyaluronic acid creates a thicker, gel-like texture that sits on the skin’s surface—ideal for hydration and barrier support. Low molecular weight HA goes deep and holds up to 1,000x its weight in water. If you’re not applying it to damp skin and sealing it in, it can actually pull moisture from deeper layers and leave skin feeling dehydrated.

  • This serum focuses on moisture retention rather than deep penetration.

  • This recipe came from @sadienardiniofficial on IG. She’s a lifelong anatomy and face exercise expert.